Effects · psyche adverse
Rebound Depression
Occurrence or worsening of depressive symptoms (depressed mood, apathy, anhedonia) after stopping a supplement that had a stimulating or antidepressant effect.
- Practices
- 2
- Habits
- 10
How we rate evidence
Probability — how likely the effect is to show up
- Very high
- High
- Medium
- Low
Evidence — where the data comes from
- Scientific Meta-analyses and randomized trials
- Clinical Clinical trials and practice
- Animal research Animal studies
- People reports User reports and anecdotes
- Theoretical Mechanistic reasoning, not yet tested
Reported as a side effect of (12)
Probability High 2 Medium 1 Low 9
Evidence Clinical 9 People reports 3
- Herbalism / Phytotherapy Practices LowClinical
- Prolonged Water Fasting Practices LowPeople reports
- Alcohol Consumption Habits LowClinical
- Compulsive Online Shopping Habits MediumClinical
- Digital Detox Habits LowClinical
- Drug Use Habits HighClinical
- Energy Drink Consumption Habits LowPeople reports
- Excessive Caffeine Intake Habits LowClinical
- Excessive Social Media Use Habits LowClinical
- Inhalant Abuse Habits HighPeople reports
- Over-the-Counter Drug Abuse Habits LowClinical
- Reckless Driving Habits LowClinical
Mitigated by (37)
- 5-HTP Supplements People reports
- 9-Me-BC Supplements People reports
- Adrafinil Supplements People reports
- Aniracetam Supplements People reports
- Bromantane Supplements People reports
- Caffeine Supplements People reports
- Clomiphene Supplements People reports
- Coluracetam Supplements People reports
- DHEA Supplements People reports
- Dihexa Supplements People reports
- DL-Phenylalanine (DLPA) Supplements People reports
- Dutasteride Supplements People reports
- Ethanol (alcohol) Supplements Theoretical
- Fasoracetam Supplements People reports
- Guarana Supplements People reports
- IDRA-21 Supplements People reports
- Ligandrol LGD-4033 Supplements People reports
- Magnolia Bark Extract Supplements Theoretical
- Methionine Supplements Clinical
- Modafinil Supplements People reports
- Mucuna Pruriens (Velvet Bean) Supplements People reports
- Noopept Supplements People reports
- NSI-189 Supplements People reports
- Phenibut Supplements People reports
- Phenylalanine Supplements People reports
- Phenylpiracetam (Phenotropil) Supplements People reports
- Piracetam Supplements People reports
- Pregnenolone Supplements People reports
- Propranolol Supplements People reports
- SAM-e Supplements People reports
- Selank Supplements People reports
- Selegiline Supplements Clinical
- St. John's Wort Supplements Clinical
- Sulbutiamine Supplements People reports
- Sunifiram Supplements People reports
- Tryptophan Supplements People reports
- Unifiram Supplements People reports