Effects · psyche adverse
Depression
Occurrence or worsening of symptoms of depression (sadness, loss of interest, apathy) during supplement intake. May be related to effects on neurotransmitters or hormonal balance.
- Supplements
- 9
- Practices
- 28
- Habits
- 64
How we rate evidence
Probability — how likely the effect is to show up
- Very high
- High
- Medium
- Low
Evidence — where the data comes from
- Scientific Meta-analyses and randomized trials
- Clinical Clinical trials and practice
- Animal research Animal studies
- People reports User reports and anecdotes
- Theoretical Mechanistic reasoning, not yet tested
Reported as a side effect of (101)
Probability Very high 10 High 21 Medium 21 Low 49
Evidence Clinical 37 People reports 15 Theoretical 49
- Anastrozole Supplements LowTheoretical
- Cerebrolysin Supplements LowClinical
- DMAE Supplements LowPeople reports
- Dutasteride Supplements LowClinical
- Ligandrol LGD-4033 Supplements LowPeople reports
- Modafinil Supplements LowTheoretical
- Oxiracetam Supplements LowPeople reports
- Pregnenolone Supplements LowPeople reports
- Propranolol Supplements LowClinical
- Acceptance and Commitment Therapy Practices LowTheoretical
- Cognitive Behavioral Therapy Practices LowClinical
- Couples Therapy Practices LowClinical
- Dance/Movement Therapy Practices LowClinical
- Dialectical Behavior Therapy Practices MediumClinical
- Digital Art Creation Practices MediumTheoretical
- Existential Therapy Practices LowClinical
- Expressive Writing Practices LowClinical
- Family Therapy Practices LowClinical
- Fasting Mimicking Diet Practices LowPeople reports
- Focused Attention Meditation Practices LowClinical
- Detailed Food Diary Practices LowClinical
- Group Therapy Practices LowClinical
- Habit Tracking Journal Practices LowClinical
- Holotropic Breathwork Practices LowPeople reports
- Interpersonal Therapy Practices MediumClinical
- Isochronic Tones Practices LowPeople reports
- Nutrition Tracking Practices LowClinical
- Plant-Based Diet Practices LowPeople reports
- Psychodynamic Therapy Practices MediumClinical
- Raja Yoga Practices LowClinical
- Rebirthing Breathwork Practices LowPeople reports
- Sleep Tracking Practices LowClinical
- Cycle Symptom Logging Practices LowPeople reports
- Trail Running Practices LowClinical
- Vipassana Meditation Practices MediumClinical
- Prolonged Water Fasting Practices MediumPeople reports
- Zazen Meditation Practices LowClinical
- Using Alcohol as a Sleep Aid Habits MediumTheoretical
- Alcohol Consumption Habits MediumTheoretical
- All-or-Nothing (Black and White) Thinking Habits HighTheoretical
- Avoid Sugar Habits LowPeople reports
- Binge Eating Episodes Habits Very highTheoretical
- Binge-Watching TV Shows for Hours Habits MediumClinical
- Blaming Others for Personal Problems Habits HighClinical
- Suppressing Emotions Habits HighTheoretical
- Bulimia Habits Very highTheoretical
- Cardiovascular Exercise Habits LowTheoretical
- Catastrophizing (Assuming the Worst) Habits HighTheoretical
- Chronic Complaining Habits HighTheoretical
- Cigarette Smoking Habits HighTheoretical
- Compulsive Online Shopping Habits Very highTheoretical
- Compulsively Checking Phone Notifications Habits MediumTheoretical
- People-Pleasing to Your Own Detriment Habits Very highTheoretical
- Digital Detox Habits LowClinical
- Doomscrolling (Consuming Negative News) Habits HighTheoretical
- Drug Use Habits Very highTheoretical
- Avoiding Difficult Emotions Habits HighTheoretical
- Emotional Eating Habits MediumClinical
- Energy Drink Consumption Habits LowPeople reports
- Engaging in Conflict Habits HighTheoretical
- Engaging in Negative Gossip Habits MediumClinical
- Excessive Caffeine Intake Habits LowClinical
- Excessive Video Gaming Habits LowClinical
- Excessive Pornography Consumption Habits MediumClinical
- Excessive Social Media Use Habits HighTheoretical
- Excessive Sugar Consumption Habits MediumTheoretical
- Excessive Worrying Habits HighTheoretical
- Fast Food Consumption Habits LowTheoretical
- Inactive Lifestyle Habits MediumTheoretical
- Inhalant Abuse Habits HighPeople reports
- Insufficient Sleep Habits MediumTheoretical
- Intermittent Fasting Habits LowPeople reports
- Irregular Sleep-Wake Schedule Habits MediumTheoretical
- Insufficient Fruit and Vegetable Intake Habits LowTheoretical
- Maladaptive Perfectionism Habits Very highTheoretical
- Meditation Habits LowTheoretical
- Mindless Scrolling on Devices Habits HighTheoretical
- Monitor Blood Glucose Habits MediumTheoretical
- Engaging in Negative Self-Talk Habits Very highTheoretical
- Not eating enough Habits HighTheoretical
- Comparing Self Negatively to Others Online Habits HighTheoretical
- Chronic Oversleeping Habits MediumTheoretical
- Maintaining Poor Posture Habits LowClinical
- Practice Mindfulness Habits LowClinical
- Eating Highly Processed Foods Habits LowTheoretical
- Chronic Procrastination Habits HighTheoretical
- Prolonged Sitting Habits HighTheoretical
- Revenge Bedtime Procrastination Habits LowTheoretical
- Ruminating on Past Mistakes Habits HighTheoretical
- Using Screens in Bed Habits LowTheoretical
- Seeking Constant External Validation Habits MediumClinical
- Engaging in Self-Sabotaging Behaviors Habits Very highTheoretical
- Self Skin Examination Habits LowClinical
- Compulsive Skin Picking Habits Very highTheoretical
- Self-Imposed Social Isolation Habits Very highTheoretical
- Using Anabolic Steroids Habits MediumClinical
- Poor Financial Management Habits HighTheoretical
- Teeth Grinding (Bruxism) Habits LowClinical
- Track Body Composition Habits LowClinical
- Unrealistic Expectations of Self Habits HighTheoretical
- Working Excessive Hours Habits HighTheoretical
Mitigated by (2)
- Nicotine Supplements Theoretical
- Phenylpiracetam (Phenotropil) Supplements People reports