Effects · mind adverse
Tolerance Development
Gradual decrease in the effect of a supplement at the same dose, requiring an increase in dosage to achieve the original result. Can lead to the risk of overdose and dependence.
- Supplements
- 21
- Practices
- 2
- Habits
- 11
How we rate evidence
Probability — how likely the effect is to show up
- Very high
- High
- Medium
- Low
Evidence — where the data comes from
- Scientific Meta-analyses and randomized trials
- Clinical Clinical trials and practice
- Animal research Animal studies
- People reports User reports and anecdotes
- Theoretical Mechanistic reasoning, not yet tested
Reported as a side effect of (34)
Probability Very high 7 High 5 Medium 7 Low 15
Evidence Clinical 5 People reports 17 Theoretical 12
- Adrafinil Supplements MediumTheoretical
- Agmatine Sulfate Supplements LowPeople reports
- Amanita Regalis Supplements MediumPeople reports
- Bromantane Supplements MediumPeople reports
- Caffeine Supplements HighTheoretical
- Coluracetam Supplements LowPeople reports
- Dihexa Supplements LowPeople reports
- Eleuthero Supplements LowTheoretical
- Honokiol Supplements LowPeople reports
- IDRA-21 Supplements MediumPeople reports
- Melatonin Supplements LowPeople reports
- Modafinil Supplements MediumTheoretical
- Mucuna Pruriens (Velvet Bean) Supplements LowPeople reports
- Phenibut Supplements Very highClinical
- Phenylpiracetam (Phenotropil) Supplements HighPeople reports
- Pregnenolone Supplements LowPeople reports
- Selank Supplements LowPeople reports
- Sulbutiamine Supplements LowPeople reports
- Sunifiram Supplements MediumPeople reports
- Unifiram Supplements MediumPeople reports
- Valerian Root Supplements LowPeople reports
- Herbalism / Phytotherapy Practices LowClinical
- Isochronic Tones Practices LowPeople reports
- Alcohol Consumption Habits HighTheoretical
- Binge-Watching TV Shows for Hours Habits LowClinical
- Compulsive Online Shopping Habits Very highTheoretical
- Drug Use Habits Very highTheoretical
- Energy Drink Consumption Habits HighTheoretical
- Excessive Caffeine Intake Habits Very highTheoretical
- Excessive Pornography Consumption Habits Very highTheoretical
- Inhalant Abuse Habits Very highTheoretical
- Reckless Driving Habits LowClinical
- Compulsive Skin Picking Habits HighClinical
- Vaping or E-Cigarette Use Habits Very highTheoretical