Effects · health adverse
Increased Liver Load
Increased workload on the liver required to metabolize and eliminate supplement components. With long-term use or high doses, can lead to elevated liver enzymes (ALT, AST) and risk of hepatotoxicity.
- Supplements
- 25
- Practices
- 3
- Habits
- 5
How we rate evidence
Probability — how likely the effect is to show up
- Very high
- High
- Medium
- Low
Evidence — where the data comes from
- Scientific Meta-analyses and randomized trials
- Clinical Clinical trials and practice
- Animal research Animal studies
- People reports User reports and anecdotes
- Theoretical Mechanistic reasoning, not yet tested
Reported as a side effect of (33)
Probability High 2 Medium 9 Low 22
Evidence Clinical 15 People reports 2 Theoretical 16
- 9-Me-BC Supplements LowTheoretical
- Adrafinil Supplements MediumTheoretical
- Anastrozole Supplements LowTheoretical
- CBD Supplements MediumClinical
- Cinnamon Extract Supplements MediumClinical
- Conjugated Linoleic Acid (CLA) Supplements LowClinical
- DHEA Supplements LowClinical
- Diindolylmethane (DIM) Supplements LowTheoretical
- Dutasteride Supplements LowClinical
- Ethanol (alcohol) Supplements MediumTheoretical
- Fadogia Agrestis Supplements LowClinical
- Gymnema Sylvestre Supplements LowPeople reports
- Indole-3-Carbinol (I3C) Supplements LowClinical
- Iron Supplements LowTheoretical
- Kava Kava Supplements LowTheoretical
- Ligandrol LGD-4033 Supplements MediumClinical
- Panax Ginseng Supplements LowPeople reports
- Resveratrol Supplements LowTheoretical
- Selenium Supplements LowClinical
- Spirulina Supplements LowTheoretical
- St. John's Wort Supplements LowTheoretical
- Tauroursodeoxycholic acid (TUDCA) Supplements LowClinical
- Valerian Root Supplements LowClinical
- Vitamin A Supplements LowTheoretical
- Vitamin B3 Supplements LowClinical
- Herbalism / Phytotherapy Practices LowClinical
- Naturopathy Practices LowTheoretical
- Prolonged Water Fasting Practices MediumTheoretical
- Using Alcohol as a Sleep Aid Habits MediumTheoretical
- Binge Eating Episodes Habits HighTheoretical
- Emotional Eating Habits MediumClinical
- Fast Food Consumption Habits HighTheoretical
- Engaging in Self-Sabotaging Behaviors Habits MediumClinical