Effects · health
SHBG Level Reduction
Decrease in the concentration of sex hormone-binding globulin (SHBG) in the blood. This can lead to an increase in the levels of free (biologically active) forms of testosterone and estrogens.
- Supplements
- 8
- Stacks
- 1
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Highest probability, strongest evidence
- DHEASupplementsMediumClinicalDHEA supplementation can lead to a modest decrease in Sex Hormone Binding Globulin (SHBG) levels, which may increase the amount of free, biologically active testosterone and estrogen available to tissues, thereby enhancing their effects.
- InositolSupplementsMediumClinicalD-Chiro-Inositol, a component of the blend, can influence Sex Hormone-Binding Globulin (SHBG) levels, potentially increasing the bioavailability of free, active sex hormones, which is beneficial in certain hormonal conditions.
- Nettle RootSupplementsMediumClinicalCompounds in nettle root, particularly certain lignans, may bind to sex hormone-binding globulin (SHBG), which could theoretically increase the amount of free, biologically active testosterone available in the bloodstream. While biologically plausible, users may not always perceive a direct effect on libido or energy.
- Indole-3-Carbinol (I3C)SupplementsLowClinicalI3C and DIM may subtly influence sex hormone-binding globulin (SHBG) levels in some individuals, potentially leading to a slight increase in the bioavailability of free testosterone or estrogen.
- Tongkat AliSupplementsVery highTheoreticalTongkat Ali contains bioactive compounds that directly inhibit Sex Hormone-Binding Globulin (SHBG), a protein that binds to sex hormones. By reducing SHBG, more free (biologically active) testosterone becomes available, which is a key mechanism behind many of its benefits, though this specific effect is not consciously felt by users.
How we rate evidence
Probability — how likely the effect is to show up
- Very high
- High
- Medium
- Low
Evidence — where the data comes from
- Scientific Meta-analyses and randomized trials
- Clinical Clinical trials and practice
- Animal research Animal studies
- People reports User reports and anecdotes
- Theoretical Mechanistic reasoning, not yet tested
Increased by
Probability Very high 1 High 3 Medium 3 Low 1
Evidence Clinical 4 Theoretical 4
Very high probability (1)
- Tongkat Ali Supplements Theoretical
High probability (3)
- Boron Supplements Theoretical
- Ligandrol LGD-4033 Supplements Theoretical
- Shilajit Supplements Theoretical
Medium probability (3)
- DHEA Supplements Clinical
- Inositol Supplements Clinical
- Nettle Root Supplements Clinical
Low probability (1)
- Indole-3-Carbinol (I3C) Supplements Clinical