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Effects · health adverse

Heart Valve Damage

Structural changes in heart valves (thickening, insufficiency), leading to impaired function. A very rare but serious side effect, historically linked to certain drugs (fenfluramine), theoretically possible with long-term use of potent serotonergic agents.

Supplements
1
How we rate evidence

Probability — how likely the effect is to show up

  • Very high
  • High
  • Medium
  • Low

Evidence — where the data comes from

  • Scientific Meta-analyses and randomized trials
  • Clinical Clinical trials and practice
  • Animal research Animal studies
  • People reports User reports and anecdotes
  • Theoretical Mechanistic reasoning, not yet tested

Reported as a side effect of (1)

Probability Low 1
Evidence Theoretical 1

Related effects