Effects · health
Prolactin Level Reduction
Decrease in the concentration of the hormone prolactin in the blood, which may be relevant in cases of hyperprolactinemia and related conditions (e.g., menstrual cycle disorders, decreased libido).
- Supplements
- 4
- Practices
- 1
- Stacks
- 2
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Highest probability, strongest evidence
- Vitamin B6SupplementsMediumClinicalThe active P5P form of B6 can help regulate prolactin levels by directly inhibiting its release, potentially beneficial for individuals with elevated prolactin or those seeking hormonal balance, though effects vary.
- CabergolineSupplementsVery highTheoreticalCabergoline potently binds to and activates dopamine D2 receptors on pituitary lactotrophs, directly inhibiting prolactin synthesis and release. This highly effective mechanism makes it the gold standard for reducing elevated prolactin levels, with a very high success rate.
- Vitex Agnus-CastusSupplementsVery highTheoreticalBy acting on dopamine D2 receptors, Vitex effectively lowers elevated prolactin levels, which can reduce breast tenderness and restore menstrual regularity often seen with hyperprolactinemia.
- Herbalism / PhytotherapyPracticesHighTheoreticalHelps lower excessive prolactin levels, balancing hormones for better health.
- Mucuna Pruriens (Velvet Bean)SupplementsHighTheoreticalDopamine is a primary inhibitor of prolactin secretion, making standardized Mucuna highly effective at reducing elevated prolactin levels, which can positively impact hormonal balance and well-being.
How we rate evidence
Probability — how likely the effect is to show up
- Very high
- High
- Medium
- Low
Evidence — where the data comes from
- Scientific Meta-analyses and randomized trials
- Clinical Clinical trials and practice
- Animal research Animal studies
- People reports User reports and anecdotes
- Theoretical Mechanistic reasoning, not yet tested
Increased by
Very high probability (2)
- Cabergoline Supplements Theoretical
- Vitex Agnus-Castus Supplements Theoretical
High probability (2)
- Herbalism / Phytotherapy Practices Theoretical
- Mucuna Pruriens (Velvet Bean) Supplements Theoretical
Medium probability (1)
- Vitamin B6 Supplements Clinical
Featured in stacks
- Stacks
Dopamine: Motivation & Drive
This stack is designed to optimize dopaminergic pathways and enhance cognitive function through a synergistic combination of nutritional precursors, essential cofactors, and behavioral interventions. It provides a key amino acid serving as a foundational building block for catecholamine neurotransmitters, including dopamine. This action is complemented by a complex supplying a direct dopamine precursor and a vital B-vitamin, ensuring efficient neurotransmitter synthesis. Non-pharmacological components, such as acute thermal exposure, structured introspection, and auditory stimulation, further support the biochemical actions by independently stimulating neurotransmitter release, enhancing focus, and promoting goal-oriented behavior. The protocol integrates daily supplementation for consistent precursor availability with specific lifestyle practices: morning cold exposure for alertness, journaling for metacognition and goal clarity, and energizing music for immediate motivational boosts. Users should monitor individual responses and consult a healthcare professional for pre-existing conditions.
- Stacks
Women's Health: Hormonal Balance
This comprehensive protocol is designed to foster optimal women's hormonal health by addressing key physiological pathways and promoting intrinsic balance. It strategically combines essential nutritional cofactors and fatty acids that modulate inflammation and support hormone synthesis, particularly involving estrogen metabolism and progesterone production. A specialized botanical and mineral complex works synergistically to stabilize endocrine function, including pituitary activity and stress resilience, crucial for maintaining rhythmic hormonal fluctuations. Integrated lifestyle practices align daily routines with the body's natural cyclical rhythms and support metabolic detoxification, while also providing profound relaxation to mitigate stress, a significant disruptor of endocrine harmony. This multi-faceted approach aims to enhance reproductive well-being, alleviate cycle-related discomforts, and improve overall vitality by optimizing the body's inherent capacity for self-regulation. Individuals should consult a healthcare professional, especially concerning iron supplementation and specific dosages.